Caveolin-1 deficiency alleviates palmitate-induced intracellular lipid accumulation and inflammation in pancreatic β cells
J. physiol. biochem
; 80(1): 175-188, Feb. 2024. ilus, graf
Artigo
em Inglês
| IBECS
| ID: ibc-EMG-575
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Lipotoxicity-induced pancreatic β cell damage is a strong predictor of type 2 diabetes mellitus (T2DM). Our previous work showed that Caveolin-1 (Cav-1) depletion decreased β-cell apoptosis and improved β-cell viability. Further microarray analysis indicated significant changes in the expression of genes related to fatty acid metabolism and inflammation. The objective of this study was to explore the role of Cav-1 in intracellular lipid accumulation and inflammation in β cells under lipotoxic conditions. Here, we established a β-cell-specific Cav-1 knockout (β-Cav-1 KO) mouse model and a CAV-1 depleted β cell line (NIT-1). We found that Cav-1 silencing significantly reduced palmitate (PA)-induced intracellular triglyceride (TG) accumulation and decreased proinflammatory factor expression in both the mouse and cell models. Further mechanistic investigation revealed that amelioration of lipid metabolism was achieved through the downregulation of lipogenic markers (SREBP-1c, FAS and ACC) and upregulation of a fatty acid oxidation marker (CPT-1). Meanwhile, decrease of inflammatory cytokines (IL-6, TNF-α, and IL-1β) secretion was found with the involvement of the IKKβ/NF-κB signaling pathways. Our findings suggest that Cav-1 is of considerable importance in regulating lipotoxicity-induced β-cell intracellular lipid accumulation and inflammation. (AU)
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Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Palmitatos
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Células Secretoras de Insulina
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Caveolina 1
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Inflamação
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Artéria Pulmonar
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Qualidade de Vida
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Asma
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Sarcoma
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Aleitamento Materno
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Bronquiectasia
Tipo de estudo:
Estudo de etiologia
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Avaliação de tecnologias de saúde
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Estudo observacional
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Estudo de prevalência
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Estudo prognóstico
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Fatores de risco
Aspecto:
Preferência do paciente
Limite:
Humanos
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Adulto
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Idoso
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Masculino
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Adolescente
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Feminino
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Recém-Nascido
País/Região como assunto:
América do Sul
/
Chile
Idioma:
Inglês
/
Espanhol
Revista:
Arch. bronconeumol. (Ed. impr.)
/
J. physiol. biochem
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An. pediatr. (2003. Ed. impr.)
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Nutr. hosp
Ano de publicação:
2023
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2022
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2024
Tipo de documento:
Artigo
Instituição/País de afiliação:
The Third Affiliated Hospital of Sun Yat-Sen University/China
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Clínica Universidad de Navarra/Spain
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Fundación SCHEFRES Sociedad Chilena para la Educación Física, Recreación y la Salud/Chile
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Hospital Clínic/Spain
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Hospital La Fe/Spain
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Hospital Sant Pau/Spain
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Hospital Universitari de Bellvitge/Spain
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Hospital do Salnés/España
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Pontificia Universidad Católica de Valparaíso/Chile
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Universidad Andres Bello/Chile