Elevated high mobility group A2 expression in liver cancer predicts poor patient survival
Rev. esp. enferm. dig
; 112(1): 27-33, ene. 2020. tab, graf
Artigo
em Inglês
| IBECS
| ID: ibc-196005
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
BACKGROUND:
liver cancer is a malignant tumor with a high morbidity and mortality that endangers human health. High mobility group A2 (HMGA2) is a chromosome associated protein that participates in embryogenesis, tissue development, tumorigenesis and development.OBJECTIVE:
to explore the relationship between HMGA2 expression and the clinicopathological parameters and survival of liver cancer patients using The Cancer Genome Atlas Liver Hepatocellular Carcinoma (HCC) data.METHODS:
RNA-sequencing data and the corresponding clinical characteristics of the patients were downloaded from the Atlas database. The Chi-squared test was used to assess the relationship between HMGA2 expression and clinical variables. Cox regression analysis was used to compare survival rates between the high- and low-expressing groups; the p-values and Kaplan-Meier survival curves were compared using the log-rank test.RESULTS:
RNA-seq data from 373 cases of liver cancer cases were analyzed. HMGA2 was overexpressed in liver cancer and significantly associated with gender (p = 0.0357), T classification (p = 0.0063), clinical classification (p = 0.0026) and overall survival (p = 0.0386). According to the multivariate analysis, HMGA2 could independently predict overall survival in liver cancer.CONCLUSIONS:
HMGA2 independently predicts poor prognosis in liver cancer and serves as a molecular marker to determine disease prognosisRESUMEN
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Espanha
Base de dados:
IBECS
Assunto principal:
Biomarcadores Tumorais
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Proteína HMGB2
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Neoplasias Hepáticas
Limite:
Humanos
Idioma:
Inglês
Revista:
Rev. esp. enferm. dig
Ano de publicação:
2020
Tipo de documento:
Artigo
Instituição/País de afiliação:
China-Japan Union Hospital of Jilin University/china
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The First Hospital of Jilin University/China
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The Second Hospital of Jilin University/China