Correlation between carcinoembryonic antigen (CEA) expression and EGFR mutations in non-small-cell lung cancer: a meta-analysis / Correlación entre la expresión del antígeno carcinoembrionario (CEA) y las mutaciones de EGFR en el cáncer de pulmón de células no pequeñas: un metanálisis
Clin. transl. oncol. (Print)
; Clin. transl. oncol. (Print);26(4): 991-1000, Abr. 2024. ilus
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Localização: ES15.1 - BNCS
ABSTRACT
Objectives: The purpose of this meta-analysis was to investigate the relationship between serum carcinoembryonic antigen (CEA) expression and epidermal growth factor receptor (EGFR) mutation status in non-small cell lung cancer (NSCLC). Methods: Databases such as PubMed, Cochrane, EMBASE and Google Scholar were systematically searched to identify studies assessing the association of serum CEA expression with EGFR mutations. Across 19 studies, 4168 patients were included between CEA expression and EGFR mutations odds ratio (OR) conjoint analysis of correlations. Results: Compared with CEA-negative NSCLC, CEA-positive tumors had an increased EGFR mutation rate (OR = 1.85, 95% confidence interval: 1.482.32, P < 0.00001). This association was observed in both stage IIIB/IV patients (OR = 1.60, 95% CI: 1.182.15, P = 0.002) and stage IIIIA (OR = 1.67, 95% CI: 1.012.77, P = 0.05) patients. In addition, CEA expression was associated with exon 19 (OR = 1.97, 95% CI: 1.253.11, P = 0.003) and exon 21 (OR = 1.51, 95% CI: 1.072.12, P = 0.02) EGFR mutations. In ADC pathological type had also showed the correlation (OR = 1.84, 95% CI: 1.312.57, P = 0.0004). Conclusions: This meta-analysis indicated that serum CEA expression was associated with EGFR mutations in NSCLC patients. The results of this study suggest that CEA level may play a predictive role in the EGFR mutation status of NSCLC patients. Detecting serum CEA expression levels can give a good suggestion to those patients who are confused about whether to undergo EGFR mutation tests. Moreover, it may help better plan of the follow-up treatment.(AU)
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Coleções:
06-national
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ES
Base de dados:
IBECS
Assunto principal:
Pandemias
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Parafusos Ósseos
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Infecções por Coronavirus
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Osteotomia
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Patologia
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Pediatria
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Qualidade de Vida
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Insuficiência Respiratória
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Infecções Respiratórias
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Espanha
Tipo de estudo:
Etiology_studies
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Guideline
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Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Aspecto:
Determinantes_sociais_saude
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Patient_preference
Limite:
Humans
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Male
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Female
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Aged
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Newborn
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Pregnancy
País/Região como assunto:
Europa
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America do sul
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Colombia
Idioma:
Es
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En
Revista:
An. pediatr. (2003. Ed. impr.)
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Rev. esp. cir. ortop. traumatol. (Ed. impr.)
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Aten. prim. (Barc., Ed. impr.)
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Clin. transl. oncol. (Print)
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Gastroenterol. hepatol. (Ed. impr.)
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Int. microbiol
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Med. clín (Ed. impr.)
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Med. oral patol. oral cir. bucal (Ed.impr.)
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Med. oral patol. oral cir. bucal (Internet)
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Nutr. clín. diet. hosp
Ano de publicação:
2022
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2023
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2024
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2021
Tipo de documento:
Article