Limited proteolysis of human and rabbit immunoglobulins by snake venoms produces Fab-like fragments
Braz. j. med. biol. res
; 23(12): 1233-5, 1990. ilus
Article
em En
| LILACS
| ID: lil-103649
Biblioteca responsável:
BR1.1
ABSTRACT
Rabbit and, to a lesser extent, human immunoglobulins (IgGs) are cleaved by snake venoms. The snake venom proteases active on IgGs release fragments which behave on SDS-PAGE like Fab units similar to those release by the thiol-activated enzymes. However, in contrast to the cysteine proteases, the activity of snake venom proteases on IgGs is not only blocked by metal chelating agents but is also inhibited by thiol compounds. The snake enzymes active on IgG are metalloproteases
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Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Venenos de Serpentes
/
Imunoglobulina G
/
Fragmentos Fab das Imunoglobulinas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Braz. j. med. biol. res
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
1990
Tipo de documento:
Article
País de publicação:
Brasil