Acute effect of the somatostatin analogue sms-201995 on plasma glucose and triglycerides in insulin-dependent diabetic patients
Braz. j. med. biol. res
; 25(6): 593-600, 1992. tab, ilus
Artigo
em Inglês
| LILACS
| ID: lil-109073
Biblioteca responsável:
BR26.1
ABSTRACT
The effect of the long-acting somatostatin analogue SMS-201995 on diabetes control was assessed in 6 insulin-dependent diabetic patients (3 men and 3 women agged 19-38 years). Plasma glucose and triglyceride profiles were obtained ion 4 consecutive days, from 800 a.m. to 200 p. m. On the first 2 days the patients received their usual dose of insulin and ate at 800 a. m. and noon. On the third and fourth days they received 1/3 of their usual insulin dose together with 100 ug SMS-201995 injected subcutaneously. Postprandial glucose and triglyceride increases were blunted during the 360 min of observation on both day after SMS-201995 administration. The areas under the glucose-time plots fell from 23.72 ñ 12.29 (mean ñ SD) to 7.98 ñ 14.26 (P<0.05) and the areas under the triglyceride-time plots from 10.51 ñ 9.01 to -3.15 ñ 4.30 g. min.dl-1 (P<0.01). No adverse rfeactions were observed after SMS-201995 administration for 2 days. We conclude that administration of the somatostatin analogue SMS-201995 may be beneficial for insulin-dependent diabetic patients
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Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Triglicerídeos
/
Glicemia
/
Somatostatina
/
Diabetes Mellitus
/
Diabetes Mellitus Tipo 1
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1992
Tipo de documento:
Artigo