Malaria parasites: enzymes involved in red blood cell invasion
Braz. j. med. biol. res
; 27(2): 363-7, Feb. 1994.
Artigo
em Inglês
| LILACS
| ID: lil-140276
Biblioteca responsável:
BR26.1
RESUMO
Three enzymes have been described in malaria merozoites a serine-protease and two phospholipases. The parasite serine-protease is necessary for parasite entry into the red blood cell. This enzyme is synthesized by intraerythrocytic schizonts as a glycolipid-anchored membrane precursor, harbouring a performed serine-protease active site but not detectable proteolytic activity. Detection of the enzymatic activity correlates with the solubilisation of the enzyme by a parasite glycolipid-specific phospholipase C in merozoites. A third enzyme has been detected with glycolipid-degrading activity, presumably a lipase A. These activities participate in a biochemical cascade originating with the attachment of the merozoite to the red blood cell, including the translocation of the phospholipase C to the membrane-bound protease, the solubilisation/activation of the protease and its secretion at the erytrocyte/parasite junction and ending with the entry of the parasite into the host cell. Both the phospholipase C and the lipase A might generate secondary messages in the merozoite. Our current knowledge concerning these enzymes is presented
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Coleções:
Bases de dados internacionais
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Malária
/
Doenças Negligenciadas
Base de dados:
LILACS
Assunto principal:
Fosfolipases Tipo C
/
Eritrócitos
/
Serina Proteases
/
Lipase
/
Malária
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1994
Tipo de documento:
Artigo
/
Congresso e conferência