Your browser doesn't support javascript.
loading
Antischistosomal activity of acridanone-hydrazones in Cebus monkeys experimentally infected with the SJ strain of Schistosoma mansoni
Rev. Soc. Bras. Med. Trop ; Rev. Soc. Bras. Med. Trop;28(3): 179-83, jul.-set. 1995. ilus, tab
Article em En | LILACS | ID: lil-163732
Biblioteca responsável: BR1.1
RESUMO
In this study, four compounds where utilized at the dose of 12.5mg/kg body weight, p.o., to treat Cebus monkeys experimentally infected with about 200 cercariae of Schistosoma mansoni (SJ strain), via transcutaneous route. The oograms performed with rectal snips, as well as stool examinations carried out periodically, showed no viable eggs of the parasite, from day 29 to 226 post-treatment. The perfusion undertaken after killing the animals showed absence of worms in the treated monkeys, whereas 83 worms were recovered from the control, thus corroborating the results obtained by means of oograms and coproscopy. These results confirm the efficacy of 9-acridanonehydrazones previously tested against the LE strain of S. mansoni. The low curative dose and apparent absence of toxicity render these drugs an important therapeutic reserve, taking into consideration the reports on the resistance of S. mansoni to the modern drugs oxamiziquine and praziquantel.
Assuntos
Buscar no Google
Coleções: 01-internacional Base de dados: LILACS Assunto principal: Esquistossomicidas / Acridinas / Esquistossomose mansoni / Hidrazonas Limite: Animals Idioma: En Revista: Rev. Soc. Bras. Med. Trop Assunto da revista: MEDICINA TROPICAL Ano de publicação: 1995 Tipo de documento: Article País de publicação: Brasil
Buscar no Google
Coleções: 01-internacional Base de dados: LILACS Assunto principal: Esquistossomicidas / Acridinas / Esquistossomose mansoni / Hidrazonas Limite: Animals Idioma: En Revista: Rev. Soc. Bras. Med. Trop Assunto da revista: MEDICINA TROPICAL Ano de publicação: 1995 Tipo de documento: Article País de publicação: Brasil