Felodipino en el tratamiento de la hipertensión arterial esencial de adultos mayores / Felodipine in the treatment of essential arterial hypertension in elders
Rev. méd. Chile
; 124(7): 821-7, jul. 1996. tab, graf
Artigo
em Espanhol
| LILACS
| ID: lil-174909
Biblioteca responsável:
CL1.1
ABSTRACT
Felodipine is a calcium channel inhibitor with high vascular selectivity. To studu the effectiveness of felodipine in the treatment of essential hypertension in subjects older than 64 years old, 50 subjects were studied. After a washout period of 4 weeks, subjects received a placebo for 2 weeks followed by the active drug given in an initial dose of 5 mg/day, adjusted to 10 and 20 mg every 21 days if normal blood pressure levels were not attained. Compared to the placebo period, Felodipine treatment reduced blood pressure from 173ñ7.5/102ñ3.3 mm Hg to 158ñ6.3/91ñ4.4 mm Hg. There was no orthostatic reduction of blood pressure and 87 percent of subjects attained systolic and diastolic pressure levels below 140 and 90 mm Hg respectively. Adverse reactions (edema, cephalea and flushing) were reported by 38 percent of subjects and in 3, the drug was discontinued. There were no changes in laboratory parameters during the treatment period. Quality life improved during treatment in the items of concentration, health status perception, mood, physical condition, depression, effects of hypertension on life evets and initiative. Felodipine is effective in the treatment of elders with essential hypertension
Buscar no Google
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Felodipino
/
Hipertensão
Tipo de estudo:
Ensaio clínico controlado
/
Guia de prática clínica
Aspecto:
Preferência do paciente
Limite:
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
1996
Tipo de documento:
Artigo