Utilidad de la inmunocitoquímica en la identificación de cuerpos de Mallory: análisis teórico de su formación / Utility of immunocytochemistry in the identification of Mallory's bodies: theorical analysis of its formation
Rev. méd. Chile
; 124(10): 1193-9, oct. 1996. ilus, tab
Artigo
em Espanhol
| LILACS
| ID: lil-185168
Biblioteca responsável:
CL1.1
ABSTRACT
Mallory bodies are hepatocyte intracytoplasmic inclusions frequently observed in liver diseases. They contain altered intermediary filaments that have immunoreactivity with epidermic antikeratin antibodies (A-QEp). They also contain Ubiquitin (Ubq) a 76 residue polypeptide that has an important role in the proteolysis of rapid exchange and abnormal cytosol proteins. To standarize an immunohistochemical method for the detection of Mallory bodies in percutaneous liver biopsies. A-QEp and A-Ubq polyclonnal antibodies were used in the study of 131 percutaneous liver biopsies obtained from patients with different liver diseases. Mallory body immunoreactivity was confirmed with immunoelectron microscopy demonstrated that Mallory bodies are partially formed by altered intermediate filaments. In conclusion, antibodies againnst ubiquitin may be very useful for the detection of Mallory bodies in liver biopsies
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Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Imuno-Histoquímica
/
Corpos de Inclusão
/
Ubiquitina
/
Queratinas
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
1996
Tipo de documento:
Artigo