Los genes de la hipertensión arterial humana / The genes of human arterial hypertension
Rev. méd. Chile
; 125(3): 351-7, mar. 1997. tab, ilus
Artigo
em Espanhol
| LILACS
| ID: lil-194840
Biblioteca responsável:
CL1.1
ABSTRACT
In the last decade, two types of genes participating in the etiology of hypertension have been identified. The primary genes or blood pressure regulators are those that codify enzymes (renin, kallikrein, kininase, aminopeptidase), hormones (angiotensins, vasopressin, aldosterone, prostaglandins and atrial natriuretic peptide) and substrates (angiotensinogen and kininogen). They cause arteriolar vasodilation or vasoconstriction or sodium retention in the extravascular space. Allelic polymorphisms associated to essential hypertension have been described. The secondary genes are those that produce hereditary diseases of low prevalence, associated to hypertension in 20 to 80 percent of patients (polycystic kidney disease, pheochromocytoma, adrenal hyperplasia, hereditary nephritis). Forty genes located in all chromosomes, that are dominantly, recessively or X-linked transmitted, have thus far been idenfied. Chromosomal maps with all genic loci are presented
Buscar no Google
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Genoma
/
Hipertensão
Tipo de estudo:
Fatores de risco
Limite:
Humanos
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
1997
Tipo de documento:
Artigo