Carbohydrate epitopes: structure and presentation and the reactivity of biological ligands: recognition of alpha-D-Galp NAc and alpha-D-Galp conformational structures
Ciênc. cult. (Säo Paulo)
; 46(4): 242-8, July-Aug. 1994.
Article
em En
| LILACS
| ID: lil-196740
Biblioteca responsável:
BR1.1
RESUMO
Apart from glycolipids and glycoproteins that express A and B blood group antigens which contain terminal nonreducing units of alpha-D-Galp NAc and alpha-D-Galp respectively, there are several other glycoconjugates in nature that contain these units linked to unfucosylated saccharides or protein. They represent normal products of the action of specific glycosyl-transferases in primate and nonprimate mammalian cells, protozoa and a few other microorganisms, end-units of carbohydrate components that have not benn further processed by additional glycosylation, or neo-antigens resulting from deregulation of certain transferases as in tumor cells. Biological ligands recognizing these structures include mono and polyclonal antibodies, bacterial fimbriae and laminin. Binding depends on the linkages and sequence of the carbohydrate chain, but also on the epitope conformation as influenced by adjacent substitution, angling determined by the glycoconjugate-substrate interaction, steric hindrance and other factors. These aspects are discussed in this minireview.
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Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Carboidratos
/
Glicoconjugados
/
Epitopos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Ciênc. cult. (Säo Paulo)
Assunto da revista:
CIENCIA
Ano de publicação:
1994
Tipo de documento:
Article
País de publicação:
Brasil