Carácter adquirido de la porfiria cutánea tarda en pacientes infectados con virus C de la hepatitis / Acquired character of porphyria cutanea tarda in patients infected with hepatitis C virus
Rev. méd. Chile
; 126(3): 245-50, mar. 1998. ilus, tab
Article
em Es
| LILACS
| ID: lil-210570
Biblioteca responsável:
CL1.1
ABSTRACT
Background:
Porphyria cutanea tarda (PCT) is due to a partial defect of hepatic uroporphyrinogen decarboxylase (URO-D). In the hereditary form, both hepatic and erythrocytic enzymes are altered, whereas in the acquired form, only the hepatic enzyme fails. There is a high prevalence of hepatitis C virus infection in patients with PCT, specially in those without family history of the disease.Aim:
To study erythrocytic URO-D activity in order to find out wether hepatitis C virus infection is associated to the acquired form of PCT or unveils an inactive hereditary form. Patients andmethods:
URO-D activity was measured in red blood cells of normal controls, hepatitis C virus carriers without symptoms of PCT and patients with PCT, with and without family history of the disease, with and without anti hepatitis C virus antibodies.Results:
URO-D activity was similar in normal controls, patients with chronic liver disease associated to hepatitis C virus, and in patients with PCT without family history of the disease with and without hepatitis C virus antibodies. URO-D activity was lower in patients with PCT and family history of the disease, with and without hepatitis C virus antibodies.Conclusions:
PCT in patients with hepatitis C virus infection is due to an acquired alteration of hepatic URO-D. Hepatitis C virus does not modify erythrocytic URO-D
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Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Porfiria Cutânea Tardia
/
Hepacivirus
/
Hepatite C Crônica
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
Es
Revista:
Rev. méd. Chile
Assunto da revista:
MEDICINA
Ano de publicação:
1998
Tipo de documento:
Article
/
Project document
País de publicação:
Chile