Efecto de fracciones pépticas derivadas de la caseína en la absorción de D-xilosa y motilidad intestinal en el perro: estudio preliminar / Effect of casein derived peptides on D-xylose absorption and small intestinal motility
Rev. méd. Chile
; 126(5): 520-4, mayo 1998. ilus, tab
Artigo
em Espanhol
| LILACS
| ID: lil-216436
Biblioteca responsável:
CL1.1
ABSTRACT
Background:
The presence of food in the intestinal lumen increases absorption from an isolated intestinal loop, the mechanisms involved are unknown. Casein, and its respective hydrolysate, increased D-xylose absorption in both normal volunteers and experimental animals; this effect was associated with prolonged small intestinal transit time and a decrease of motor activity.Aims:
To separate from casein hydrolysate, groups of peptides and to investigate their effects on both D-xylose absorption and small intestinal motility. Material andmethods:
Studies were performed on five dogs with a surgically implanted duodenal cannula. Three groups of peptides were separated by means of a Silica Gel 60 column and were continously infused through the duodenal cannula. After 15 min, 5 g of D-xylose were injected in the duodenum, plasma levels were measured, and the area under the curve was estimated. Motility was recorded by means of infused catheters and external transducers.Results:
Plasma levels of D-xylose were significantly increased during the infusion of one group of peptides compared to the others. In addition, the area under the curve 3366 ñ 885 mg x min-1 observed with this group was significantly greater than the other two groups 1432 ñ 183 mg x min-1 and 1137 ñ 280 mg x min-1 respectively. No statistically significant differences in motor activity were observed between the different groups of peptides.Conclusions:
A group of peptides derived from casein was characterized by increasing D-xylose absorption. The presence of beta casomorphines might be the possible mechanism involved
Buscar no Google
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Xilose
/
Caseínas
/
Cães
/
Motilidade Gastrointestinal
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
1998
Tipo de documento:
Artigo
/
Documento de projeto