Control of CD4 gene expression: connecting signals to outcomes in T cell development
Braz. j. med. biol. res
; 32(7): 785-803, July 1999.
Artigo
em Inglês
| LILACS
| ID: lil-234883
Biblioteca responsável:
BR1.1
RESUMO
The control of CD4 gene expression is essential for proper T lymphocyte development. Signals transmitted from the T-cell antigen receptor (TCR) during the thymic selection processes are believed to be linked to the regulation of CD4 gene expression during specific stages of T cell development. Thus, a study of the factors that control CD4 gene expression may lead to further insight into the molecular mechanisms that drive thymic selection. In this review, we discuss the work conducted to date to identify and characterize the cis-acting transcriptional control elements in the CD4 locus and the DNA-binding factors that mediate their function. From these studies, it is becoming clear that the molecular mechanisms controlling CD4 gene expression are very complex and differ at each stage of development. Thus, the control of CD4 expression is subject to many different influences as the thymocyte develops
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Receptores de Antígenos de Linfócitos T
/
Linfócitos T
/
Leucemia Linfocítica Crônica de Células B
/
Linfócitos T CD4-Positivos
/
Transdução de Sinais
/
Expressão Gênica
/
Diferenciação Celular
Tipo de estudo:
Estudo prognóstico
/
Revisão sistemática
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1999
Tipo de documento:
Artigo
/
Congresso e conferência