Gen supresor de tumores p53 en neoplasias digestivas / p53 tumor supresor gene in digestive cancer
Rev. méd. Chile
; 128(11): 1269-78, nov. 2000. ilus, tab
Artigo
em Espanhol
| LILACS
| ID: lil-282155
Biblioteca responsável:
CL1.1
RESUMO
Malignant diseases of the digestive tract cause more than 50 percent of deaths due to cancer in Chile. There is a high incidence of gastric and gallbladder cancer and an increasing frequency of colorectal cancer. P53 tumor suppressor gene has a great importance in carcinogenesis and its alterations are specially important in digestive tract tumors such as colorectal cancer. There is contradictory evidence about the frequency of p53 gene or protein alterations or their biological significance. There is little information about p53 in Chile and it is mostly limited to immunohistochemical studies. This revision analyzes the frequency of p53 alterations in digestive tract tumors in Chile, using immunohistochemical and molecular biology methods. A special emphasis is given to the prognostic importance of this gene
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Genes p53
/
Genes Supressores
/
Neoplasias Gastrointestinais
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2000
Tipo de documento:
Artigo
/
Documento de projeto