Rol del virus herpes simplex en la queratitis inmune estromal / Role of herpes simplex virus in the immune stromal keratitis
Rev. méd. Chile
; 129(3): 259-63, mar. 2001.
Artigo
em Espanhol
| LILACS
| ID: lil-286860
Biblioteca responsável:
CL1.1
ABSTRACT
Background:
Herpes simplex virus (HSV) infection of the cornea is a leading cause of blindness in occidental countries and a common recurrent manifestation of it is the immune stromal keratitis (ISK). However, it is not known whether active viral replication occurs during the acute phase of the disease, because isolation of the virus by conventional culture techniques has not been accomplished.Aim:
To establish the presence of HSV in patients with ISK. Material andmethods:
Fourteen corneal swabbing samples, from active diseased eyes of patients with clinical diagnosis of ISK, were submitted to Herpchek© and PCR for the identification of HSV antigens and genome.Results:
All ISK samples were negative by both techniques.Conclusions:
It was not possible to identify HSV antigens nor their genome by the methodology used. It is likely that, they can't be detected in corneal superficial layers or probably there is no viral replication at this stage of the disease, so antiviral therapy should be reconsidered
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Ceratite Herpética
/
Simplexvirus
Limite:
Adolescente
/
Adulto
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Masculino
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2001
Tipo de documento:
Artigo
/
Documento de projeto