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Expression of c-erbB-2, p53 and c-myc proteins in male breast carcinoma: Comparison with traditional prognostic factors and survival
Mouräo Netto, M; Logullo, A. F; Nonogaki, S; Brentani, R. R; Brentani, M. M.
Afiliação
  • Mouräo Netto, M; Hospital do Câncer A.C. Camargo. BR
  • Logullo, A. F; Universidade de Säo Paulo. Faculdade de Medicina. Departamento de Radiologia. Disciplina de Oncologia. BR
  • Nonogaki, S; Instituto Adolpho Lutz. BR
  • Brentani, R. R; Instituto Ludwig de Pesquisa sobre o Câncer. Säo Paulo. BR
  • Brentani, M. M; Universidade de Säo Paulo. Faculdade de Medicina. Departamento de Radiologia. Disciplina de Oncologia. BR
Braz. j. med. biol. res ; 34(7): 887-894, July 2001. ilus, tab
Article em En | LILACS | ID: lil-298672
Biblioteca responsável: BR1.1
ABSTRACT
There are few data evaluating biological markers for men with breast cancer. The purpose of the present study was to analyze the expression of the oncogenes c-erbB-2 and c-myc and of the suppressor gene p53 by immunohistochemical techniques in archival paraffin-embedded tissue blocks of 48 male breast cancer patients, treated at the A.C. Camargo Cancer Hospital, Säo Paulo, SP, Brazil. The results were compared with clinicopathological prognostic features. Immunopositivity of c-erbB-2, p53 and c-myc was detected in 62.5, 16.7 and 20.8 percent of the cases analyzed, respectively. Estrogen and progesterone receptors were positive in 75 and 69 percent of the cases, respectively. Increasing staging was statistically associated with c-erbB-2 (P = 0.04) and weakly related to p53 positivity (P = 0.06). No significant correlation between specific survival rate (determined by the log rank test) and the molecular markers analyzed was found, whereas the number of compromised lymph nodes and advanced TNM (tumor, node, metastasis) staging were associated with diminished survival
Assuntos
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Biomarcadores Tumorais / Genes p53 / Proteína Supressora de Tumor p53 / Proteínas Proto-Oncogênicas c-myc / Receptor ErbB-2 / Neoplasias da Mama Masculina Tipo de estudo: Prognostic_studies Limite: Adult / Humans / Male Idioma: En Revista: Braz. j. med. biol. res Assunto da revista: BIOLOGIA / MEDICINA Ano de publicação: 2001 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Biomarcadores Tumorais / Genes p53 / Proteína Supressora de Tumor p53 / Proteínas Proto-Oncogênicas c-myc / Receptor ErbB-2 / Neoplasias da Mama Masculina Tipo de estudo: Prognostic_studies Limite: Adult / Humans / Male Idioma: En Revista: Braz. j. med. biol. res Assunto da revista: BIOLOGIA / MEDICINA Ano de publicação: 2001 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil