Efecto de la vitamina K oral e intramuscular sobre los factores II, VII, IX, X y PIVKA II en el recién nacido hasta los 60 días de edad: relación con la alimentación / Effect of oral or intramuscular vitamin K and feeding modality on coagulation factors in neonates under 60 days of age
Rev. méd. Chile
; 129(10): 1121-1129, oct. 2001. graf
Artigo
em Espanhol
| LILACS
| ID: lil-301903
Biblioteca responsável:
CL1.1
RESUMO
Background:
Neonates on exclusive breast feeding that do not receive vitamin K at birth are at higher risk hemorrhagic disease of the newborn.Aim:
To compare the effect of oral or intramuscular administration of vitamin K1 (VK1), on clotting factors II, VII, IX, X and PIVKA II, in children until the 60 days of age with exclusive breast feeding or mixed feeding. Patients andmethods:
Forty healthy full term infants, distributed in two groups, A 20 with mixed feeding (formula-feeding and breast-feeding) and B 20 with exclusive breast feeding, were studied. Nine infants of each group received 1 mg of VK1 intramuscularly and eleven 2 mg VK orally. 5 ml of cord blood was collected initially from each infant. Venous blood samples were taken on 15, 30 and 60 days of age.Results:
All factors increased in a progressive form reaching levels over 50 per cent at 60 days of age, in both groups. PIVKA II decreased significantly during the study period (p <0.01). Factor II increased more in children with mixed feeding that received intramuscular vitamin K, than in the rest of study groups. No other differences between groups were observed. No infant had an abnormal bleeding during the study period.Conclusions:
Oral administration of vitamin K is as effective as the intramuscular route in the prevention of the hemorrhagic disease of the newborn (Rev MÄd Chile 2001; 129 1121-9)
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Zoonoses
Base de dados:
LILACS
Assunto principal:
Vitamina K
Limite:
Feminino
/
Humanos
/
Lactente
/
Masculino
/
Recém-Nascido
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2001
Tipo de documento:
Artigo
País de afiliação:
Venezuela
Instituição/País de afiliação:
Universidad del Zulia/VE