Efecto de la terapia hormonal de reemplazo que incluye un progestágeno sobre la sensibilidad a la insulina y el perfil de lípidos en la mujer en etapa de posmenopausia / Effects of hormone replacement therapy including a progestin on insulin sensitivity and lipid profile in postmenopausal women
Rev. méd. Chile
; 129(9): 989-994, sept. 2001. tab, graf
Artigo
em Espanhol
| LILACS
| ID: lil-302028
Biblioteca responsável:
CL1.1
ABSTRACT
Background: The cardiovascular protective properties of hormone replacement therapy can be hampered when a progestin is used. Aim: To assess the effects of hormone replacement therapy with progestins on insulin sensitivity and lipid profile. Patients and methods: Twelve healthy postmenopausal women aged 45 to 55 years old were studied. Blood lipids and insulin sensitivity, determined using the insulin tolerance test, were measured at baseline and after three months of hormone replacement therapy using conjugated estrogens, 0.625 mg/day and medroxyprogesterone acetate, 5 mg/day. Results: The glucose disappearance constant was higher after the treatment period than at baseline (5.3ñ0.8 and 4.7ñ0.8 percent/min respectively, p = 0.005). Serum LDL cholesterol was also lower at the end of treatment period (124.5 ñ 30.2 and 140ñ25.4 mg/dl respectively, p = 0.019). Conclusions: In this group of postmenopausal women, a period of three months of hormone replacement therapy with a progestin improved insulin sensitivity and lowered LDL cholesterol levels
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Progestinas
/
Resistência à Insulina
/
Terapia de Reposição de Estrogênios
/
Lipídeos
Tipo de estudo:
Estudo diagnóstico
Limite:
Feminino
/
Humanos
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2001
Tipo de documento:
Artigo
País de afiliação:
México
Instituição/País de afiliação:
Centro Médico Nacional de Occidente/MX