Genetic polymorphism at position-308 in the promoter region of the tumornecrosis factor (TNF): implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population
Biol. Res
; 34(3/4): 237-241, 2001. tab
Artigo
em Inglês
| LILACS
| ID: lil-303887
Biblioteca responsável:
BR1.1
ABSTRACT
Several single-nucleotide polymorphisms have been identified in the human TNF gene promoter. The polymorphism at position-308 (TNF-308), which involves substituting G for A and designing the TNF2 allele, leads to a higher rate of TNF gene transcription than the wild-type TNF1 allele in in vitro expression studies. It has also been linked to increased susceptibility to a variety of illnesses. Using PCR-RFLP analysis we detected significant differences in the TNF-308 genotypes of Chilean and other populations. We conclude that there is a gradient in the distribution of the TNF2 allele according to ethnicity; we have also hypothesized that populations bearing a higher proportion of the TNF2 allele may have an increased predisposition toward or incidence of several chronic metabolic, degenerative, inflammatory and autoimmune diseases.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Polimorfismo Genético
/
Regiões Promotoras Genéticas
/
Fator de Necrose Tumoral alfa
/
Predisposição Genética para Doença
/
Alelos
/
Frequência do Gene
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
País/Região como assunto:
América do Sul
/
Chile
Idioma:
Inglês
Revista:
Biol. Res
Assunto da revista:
Biologia
Ano de publicação:
2001
Tipo de documento:
Artigo
País de afiliação:
Chile
Instituição/País de afiliação:
University of Chile/CL