Evaluation of Gilles de la Tourette syndrome with [99mTc] HMPAO Brain SPECT
Rev. med. nucl. Alasbimn j
; 4(15)abr. 2002. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-313225
Biblioteca responsável:
CL1.1
RESUMO
Gilles de la Tourette syndrome (GLTS) is a disorder characterized by tics and several behavioral disturbances. Although GLTS is a relatively common disorder, little is known about its pathophysiology. Previous studies with SPECT and PET were performed in a small number of patients and have shown some discordant data. The aim of this study is to evaluate brain perfusion abnormalities in patients with GLTS and to correlate them with the clinical manifestations of the syndrome. Twenty-eight patients were submitted to brain [99mTc]-HMPAO SPECT. 82 percent of the patients had abnormal studies. The most frequent finding was perfusion abnormalities in the thalami in 16 patients (57 percent) and 85 percent of patients with hyperperfusion of one or both thalami had complex motor tics. This investigation has demonstrated that brain perfusion SPECT is able to identify cortical perfusion abnormalities, associated with clinical symptoms in patients with GLTS. These abnormalities involve the pre-frontal-striatal-thalamic-cortical pathways
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Síndrome de Tourette
/
Tomografia Computadorizada de Emissão de Fóton Único
/
Tecnécio Tc 99m Exametazima
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Rev. med. nucl. Alasbimn j
Assunto da revista:
Medicina Nuclear
Ano de publicação:
2002
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade do Estado de Campinas/BR