New enamine derivatives of lapachol and biological activity
An. acad. bras. ciênc
; 74(2): 211-221, June 2002. ilus, tab
Article
em En
| LILACS
| ID: lil-314019
Biblioteca responsável:
BR1.1
ABSTRACT
A convenient synthesis of the new enamine derivatives 2-(4-morpholinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione, 2-(1-piperidinyl)-3-(3-methyl-2-butenyl)-1,4-naphtalenedione and 2-(1-pyrrolidinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione was carried out from natural 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthalenedione (lapachol) and morpholine, piperidine and pyrrolidine. The structures of the products were established mainly by NMR analysis, including 2D experiments. Biological activities of these products were evaluated against Artemia salina, Aedes aegypti and cytotoxicity using A549 human breast cells
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Naftoquinonas
/
Aminas
/
Antineoplásicos Fitogênicos
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
An. acad. bras. ciênc
Assunto da revista:
CIENCIA
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Brasil