Deteccion de secuencias homologas al gen env del virus del Tumor Mamario Murino (MMTV) en cancer de mama de pacientes argentinas / Detection of murine mammary tumor virus (MMTV) env gene-like sequences in breast cancer from Argentine patients
Medicina (B.Aires)
; 62(4): 327-323, 2002. ilus, tab
Artigo
em Espanhol
| LILACS
| ID: lil-317323
Biblioteca responsável:
BR1.1
ABSTRACT
In the last years research on the possible viral etiology of human breast cancer has been revised. Previous studies have demonstrated the presence of a Mouse Mammary Tumor Virus (MMTV) env gene-like sequence in about 38% of breast cancers from American and Italian women; these sequences are generally absent in other tumors and in normal mammary tissue. In the present study we have analyzed the presence of a 250-bp sequence of the MMTV env gene in breast cancer biopsies from Argentine patients. The retroviral fragment was present in 31% (23/74) of the tumors, only in one normal mammary tissue and in none of the fibroadenomas analYzed. Peripheral blood mononuclear cells (PBMC) from 46 cancer patients were also analyzed; the sequence was found in 17% (2/12) of the PBMC from env positive tumor patients and in 3% (1/34) of the env negatives. The results from Argentine samples are similar to those from USA and Italy, where the breast cancer incidence is alike. These findings support the hypothesis of a viral agent involved in the genesis of this neoplasia and encourage the continuation of these studies
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Infecções Tumorais por Vírus
/
Neoplasias da Mama
/
Genes env
/
Vírus do Tumor Mamário do Camundongo
/
Infecções por Retroviridae
Tipo de estudo:
Estudo diagnóstico
Limite:
Animais
/
Feminino
/
Humanos
País/Região como assunto:
América do Sul
/
Argentina
Idioma:
Espanhol
Revista:
Medicina (B.Aires)
Assunto da revista:
Medicina
Ano de publicação:
2002
Tipo de documento:
Artigo
País de afiliação:
Argentina
/
Estados Unidos
Instituição/País de afiliação:
Hospital Nacional Prof. Alejandro Posadas/AR
/
Instituto Nacional de Enfermedades Infecciosas ANLIS Dr. Carlos G. Malbrán/AR
/
New York University/US