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Technetium-99m nitrido radiopharmaceuticals with unprecedented biological properties
Duatti, Adriano; Boschi, Alessandra; Uccelli, Licia.
Afiliação
  • Duatti, Adriano; University of Ferrara. Department of Clinical & Experimental Medicine. Laboratory of Nuclear Medicine. Ferrara. IT
  • Boschi, Alessandra; University of Ferrara. Department of Clinical & Experimental Medicine. Laboratory of Nuclear Medicine. Ferrara. IT
  • Uccelli, Licia; University of Ferrara. Department of Clinical & Experimental Medicine. Laboratory of Nuclear Medicine. Ferrara. IT
Braz. arch. biol. technol ; 45(spe): 135-142, Sept. 2002. ilus, tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: lil-329818
Biblioteca responsável: BR1.1
ABSTRACT
The chemical methods for the production of technetium-99m radiopharmaceuticals containing a terminal TcFACE="Symbol">ºN triple bond have been established more than a decade ago. From that time, the chemistry of nitrido Tc-99m complexes has provided a highly efficient tool for the design and preparation of novel classes of diagnostic agents, and a number of potentially useful radiopharmaceuticals have been discovered. In particular, nitrido technetium-99m tracers have been developed for heart perfusion imaging. In this short review, the chemical and biological properties of the neutral myocardial perfusion tracer bis(N-ethoxy, N-ethyl-dithiocarbamato) nitrido Tc-99m (TcN-NOEt) will be summarized along with the preparation and preliminary biological evaluation of the first class of monocationic nitrido technetium-99m radiopharmaceuticals exhibiting improved biodistribution properties closer to those expected for an ideal perfusion imaging agent
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Idioma: Inglês Revista: Braz. arch. biol. technol Assunto da revista: Biologia Ano de publicação: 2002 Tipo de documento: Artigo País de afiliação: Itália Instituição/País de afiliação: University of Ferrara/IT

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Idioma: Inglês Revista: Braz. arch. biol. technol Assunto da revista: Biologia Ano de publicação: 2002 Tipo de documento: Artigo País de afiliação: Itália Instituição/País de afiliação: University of Ferrara/IT
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