Evaluación de la respuesta inmune celular inducida en ratones Balb/C por la proteína de envoltura del virus dengue 2 / Assessment of the cellular immune response induced in Balb/C mice with dengue virus 2 envelope protein

ABSTRACT

The cellular immune response to dengue type 2 virus envelope protein was studied. To this end, the lympho-proliferative capacity of T-lymphocytes obtained from splenocytes of animals immunized with the protein when they were stimulated by such protein and dengue 2 virus. It was realized that splenocytes proliferated significantly in response to both types of viral antigens and that the values of stimulation indexes were higher in response to the whole virus than to the protein alone. Based on the above-mentioned, it was concludes that purified dengue 2 virus envelope protein was capable of generating specific and memory responses of antigen T-cell to dengue 2 type virus.