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Alta frecuencia de lesiones precursoras de cáncer gástrico asociadas a Helicobacter pylori y respuesta al tratamiento, en Chiapas, México / High frequency of precancerous lesions of gastric cancer associated with Helicobacter pylori and response to treatment, in Chiapas, Mexico
Mohar, Alejandro.
Afiliação
  • Mohar, Alejandro; Instituto Nacional de Cancerología. MX
Gac. méd. Méx ; 138(5): 405-410, sep.-oct. 2002.
Artigo em Espanhol | LILACS | ID: lil-333695
Biblioteca responsável: BR1.1
ABSTRACT
Stomach cancer is the second cause of death in Mexico in patients with malignant tumors. This disease represents a public health problem. A strong association has been described between chronic infection with Helicobacter pylori and gastric cancer. This malignancy is preceded by a series of preneoplastic conditions, including chronic atrophic gastritis (CAG), intestinal metaplasia (IM), and dysplasia. The objective of this study was to establish the prevalence of preneoplastic conditions associated with infection of Helicobacter pylori in the state of Chiapas and its eradication with antibiotics. Persons infected with Helicobacter pylori and with CAG were identified by serology against CagA protein and serologic levels of gastrin. An endoscopy with biopsy was performed at the beginning of the study, and at 6 weeks and 1 year thereafter. A total of 281 people were enrolled and randomly assigned to treatment or placebo group. CAG was found in 59, IM in 51, and dysplasia in 13. In intent-to-treat and per-protocol analysis, Helicobacter pylori was eliminated in 70 and 76, respectively. These results indicate high frequency of preneoplastic conditions associated with Helicobacter pylori and an excellent eradication rate. They also offer a possible alternative for preventing gastric cancer.
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Lesões Pré-Cancerosas / Neoplasias Gástricas / Helicobacter pylori / Infecções por Helicobacter Tipo de estudo: Estudo de prevalência Limite: Adulto / Feminino / Humanos / Masculino País/Região como assunto: México Idioma: Espanhol Revista: Gac. méd. Méx Assunto da revista: Medicina Ano de publicação: 2002 Tipo de documento: Artigo País de afiliação: Colômbia Instituição/País de afiliação: Instituto Nacional de Cancerología/MX

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Lesões Pré-Cancerosas / Neoplasias Gástricas / Helicobacter pylori / Infecções por Helicobacter Tipo de estudo: Estudo de prevalência Limite: Adulto / Feminino / Humanos / Masculino País/Região como assunto: México Idioma: Espanhol Revista: Gac. méd. Méx Assunto da revista: Medicina Ano de publicação: 2002 Tipo de documento: Artigo País de afiliação: Colômbia Instituição/País de afiliação: Instituto Nacional de Cancerología/MX
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