Calcium- and zinc-binding proteins in intracellular transport
Biocell
; 20(3): 339-342, Dec. 1996.
Artigo
em Inglês
| LILACS
| ID: lil-335982
Biblioteca responsável:
BR1.1
RESUMO
The complex mechanism of intracellular transport is regulated by free calcium in different manners. Calcium binding proteins regulate several aspects of the vesicle fusion mechanism mediated by NSF (N-ethylmaleimide sensitive fusion factor). At least in some regulated exocytosis, calcium-binding proteins are the trigger for fusion downstream of NSF, Still, calcium-binding proteins, such as annexins, may be part of a different fusion mechanism mediating some specific transport steps or working in parallel to the NSF-dependent fusion process. Calcium is not the only ion necessary for the function of factors involved in vesicular transport. A zinc requirement has been also proposed. One of the zinc-dependent factors is probably a protein with a cysteine-rich region that coordinates zinc and binds phorbol esters. Although protein kinase C is the more prominent family of proteins carrying this domain, the factor necessary for transport does not appear to function as a kinase.
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Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Zinco
/
Transporte Biológico
/
Proteínas de Ligação ao Cálcio
/
Cálcio
/
Metaloproteínas
Limite:
Animais
Idioma:
Inglês
Revista:
Biocell
Assunto da revista:
Clulas
Ano de publicação:
1996
Tipo de documento:
Artigo
País de afiliação:
Argentina
Instituição/País de afiliação:
Universidad Nacional de Cuyo/AR