What can digital transcript profiling reveal about human cancers?
Braz. j. med. biol. res
; 36(8): 975-985, Aug. 2003. ilus
Article
em En
| LILACS
| ID: lil-340786
Biblioteca responsável:
BR1.1
ABSTRACT
Important biological and clinical features of malignancy are reflected in its transcript pattern. Recent advances in gene expression technology and informatics have provided a powerful new means to obtain and interpret these expression patterns. A comprehensive approach to expression profiling is serial analysis of gene expression (SAGE), which provides digital information on transcript levels. SAGE works by counting transcripts and storing these digital values electronically, providing absolute gene expression levels that make historical comparisons possible. SAGE produces a comprehensive profile of gene expression and can be used to search for candidate tumor markers or antigens in a limited number of samples. The Cancer Genome Anatomy Project has created a SAGE database of human gene expression levels for many different tumors and normal reference tissues and provides online tools for viewing, comparing, and downloading expression profiles. Digital expression profiling using SAGE and informatics have been useful for identifying genes that have a role in tumor invasion and other aspects of tumor progression
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Biblioteca Gênica
/
Biologia Computacional
/
Bases de Dados como Assunto
/
Perfilação da Expressão Gênica
/
Neoplasias
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Braz. j. med. biol. res
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
2003
Tipo de documento:
Article
/
Congress and conference
País de afiliação:
Brasil
/
Estados Unidos
País de publicação:
BR
/
BRASIL
/
BRASILE
/
BRAZIL
/
BRESIL