Importance of hyaluronan biosynthesis and degradation in cell differentiation and tumor formation
Braz. j. med. biol. res
; 36(8): 967-973, Aug. 2003. ilus
Article
em En
| LILACS
| ID: lil-340790
Biblioteca responsável:
BR1.1
RESUMO
Hyaluronan is an important connective tissue glycosaminoglycan. Elevated hyaluronan biosynthesis is a common feature during tissue remodeling under both physiological and pathological conditions. Through its interactions with hyaladherins, hyaluronan affects several cellular functions such as cell migration and differentiation. The activities of hyaluronan-synthesizing and -degrading enzymes have been shown to be regulated in response to growth factors. During tumor progression hyaluronan stimulates tumor cell growth and invasiveness. Thus, elucidation of the molecular mechanisms which regulate the activities of hyaluronan-synthesizing and -degrading enzymes during tumor progression is highly desired
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Diferenciação Celular
/
Transformação Celular Neoplásica
/
Receptores de Hialuronatos
/
Matriz Extracelular
/
Invasividade Neoplásica
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Braz. j. med. biol. res
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
2003
Tipo de documento:
Article
/
Congress and conference
País de afiliação:
Suécia
País de publicação:
Brasil