Distribution of naive and memory/effector CD4+ T lymphocytes and expression of CD38 on CD8+ T lymphocytes in AIDS patients with tuberculosis
Braz. j. infect. dis
; 7(2): 161-165, Apr. 2003. ilus
Artigo
em Inglês
| LILACS, Sec. Est. Saúde SP
| ID: lil-351160
Biblioteca responsável:
BR1.1
ABSTRACT
CD4+ and CD8+ T lymphocyte counts, naive and memory/effector CD4+ T subpopulations, and the expression of CD38 on CD8+ T lymphocytes were evaluated in four groups AIDS patients with tuberculosis (HIV/TB, n=14), HIV-1 infected patients (HIV, n=10), HIV-1 negative patients with tuberculosis (TB, n=20) and healthy controls (CTL, n=17). TB and HIV had fewer CD4+ T cells than CTL, with the lowest values observed in TB/HIV (p<0.001). No difference between groups was observed in the percentage of naive and memory/effector subpopulations in CD4+ T lymphocytes. TB (355 cells/mL) and HIV (517 cells/mL) had diverging effects on CD8+ T cell counts, with a marked depletion observed in HIV/TB (196 cells/mL). TB and HIV up-regulated CD38 expression on CD8+ T cells, a finding also present in TB/HIV. While the decrease of CD4+ T cell counts in HIV/TB may be attributed to HIV and tuberculosis, the decrease of CD8+ T cell counts is likely to be due to tuberculosis
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Brasil
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
Doenças Negligenciadas
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
/
Doenças Negligenciadas
/
Tuberculose
Base de dados:
LILACS
/
Sec. Est. Saúde SP
Assunto principal:
Tuberculose Pulmonar
/
Linfócitos T CD4-Positivos
/
Subpopulações de Linfócitos T
/
HIV-1
/
Infecções Oportunistas Relacionadas com a AIDS
/
Linfócitos T CD8-Positivos
/
Memória Imunológica
Tipo de estudo:
Estudo observacional
Limite:
Adulto
/
Humanos
Idioma:
Inglês
Revista:
Braz. j. infect. dis
Ano de publicação:
2003
Tipo de documento:
Artigo
Instituição/País de afiliação:
Federal University of São Paulo/BR