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Detection of pathogenic bacteria in skin lesions of patients with chiclero's ulcer: reluctant response to antimonial treatment
Isaac-Márquez, Angélica Patricia; Lezama-Dávila, Claudio Manuel.
Afiliação
  • Isaac-Márquez, Angélica Patricia; Universidad Autónoma de Campeche. Centro de Investigaciones en Enfermedades Tropicales. Campeche. MX
  • Lezama-Dávila, Claudio Manuel; Universidad Autónoma de Campeche. Centro de Investigaciones en Enfermedades Tropicales. Campeche. MX
Mem. Inst. Oswaldo Cruz ; 98(8): 1093-1095, Dec. 2003. tab
Article em En | LILACS | ID: lil-355741
Biblioteca responsável: BR1.1
RESUMO
We investigated the bacterial flora present in skin lesions of patients with chiclero's ulcer from the Yucatan peninsula of Mexico using conventional culture methods (11 patients), and an immunocolorimetric detection of pathogenic Streptococcus pyogenes (15 patients). Prevalence of bacteria isolated by culture methods was 90.9 percent (10/11). We cultured, from chiclero's ulcers (60 percent), pathogenic bacterial such as Staphylococcus aureus (20 percent), S. pyogenes (1.6 percent), Pseudomonas aeruginosa (1.6 percent), Morganella morganii (1.6 percent), and opportunist pathogenic bacteria such as Klebsiella spp. (20.0 percent), Enterobacter spp. (20 percent), and Enterococcus spp. (20 percent). We also cultured coagulase-negative staphylococci in 40 percent (4/10) of the remaining patients. Micrococcus spp. and coagulase-negative staphylococci constituted the bacterial genuses more frequently isolated in the normal skin of patients with chiclero's ulcer and healthy individuals used as controls. We also undertook another study to find out the presence of S. pyogenes by an immunocolorimetric assay. This study indicated that 60 percent (9/15) of the ulcerated lesions, but not normal controls, were contaminated with S. pyogenes. Importantly, individuals with purulent secretion and holding concomitant infections with S. pyogenes, S. aureus, P. aeruginosa, M. morganii, and E. durans took longer to heal Leishmania (L.) mexicana infections treated with antimonial drugs. Our results suggest the need to eliminate bacterial purulent infections, by antibiotic treatment, before starting antimonial administration to patients with chiclero's ulcer.
Assuntos
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Compostos Organometálicos / Úlcera Cutânea / Leishmaniose Cutânea / Meglumina / Antiprotozoários Tipo de estudo: Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Mem. Inst. Oswaldo Cruz Assunto da revista: MEDICINA TROPICAL / PARASITOLOGIA Ano de publicação: 2003 Tipo de documento: Article / Project document País de afiliação: México
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Compostos Organometálicos / Úlcera Cutânea / Leishmaniose Cutânea / Meglumina / Antiprotozoários Tipo de estudo: Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Mem. Inst. Oswaldo Cruz Assunto da revista: MEDICINA TROPICAL / PARASITOLOGIA Ano de publicação: 2003 Tipo de documento: Article / Project document País de afiliação: México