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Niveles plasmáticos de citoquinas IL-1ß, IL2 e IL-4 en niños diabéticos tipo 1 de diagnóstico reciente y su asociación con anticuerpos ß pancreáticos / Plasma levels of interleukin-1, interleukin-2 and interleukin-4 in recently diagnosed type 1 diabetic children and their association with ß-pancreatic autoantibodies
Pérez B., Francisco; Oyarzún A., Amaya; Carrasco P., Elena; Angel B., Bárbara; Albala B., Cecilia; Santos M., J. Luis.
Afiliação
  • Pérez B., Francisco; Universidad de Chile. Instituto de Nutrición y Tecnología de los Alimentos. Programa de Epidemiología Genética. CL
  • Oyarzún A., Amaya; Universidad de Chile. Instituto de Nutrición y Tecnología de los Alimentos. Programa de Epidemiología Genética. CL
  • Carrasco P., Elena; Universidad de Chile. Facultad de Medicina. Hospital San Juan de Dios. Unidad de Diabetes. Santiago. CL
  • Angel B., Bárbara; Universidad de Chile. Instituto de Nutrición y Tecnología de los Alimentos. Programa de Epidemiología Genítica. CL
  • Albala B., Cecilia; Universidad de Chile. Instituto de Nutrición y Tecnología de los Alimentos. Programa de Epidemiología Genética. CL
  • Santos M., J. Luis; Universidad de Chile. Instituto de Nutrición y TecnologÝa de los Alimentos. Programa de Epidemiología Genítica. CL
Rev. méd. Chile ; 132(4): 413-420, abr. 2004. tab
Artigo em Espanhol | LILACS | ID: lil-362905
Biblioteca responsável: CL12.1
RESUMO

Background:

Type 1 diabetes is an organ specifc autoimmune disease whose incidence is increasing worldwide. A functional imbalance in cytokine production resulting in dominance of T helper (Th1) over Th2-type response has been suggested to play a critical role in the pathogenesis of type 1 diabetes.

Aim:

To measure serum concentrations of interleukin (IL)-1ß, IL-2 and IL-4 in children with recently diagnosed type 1 diabetes and to evaluate the autoimmune response measuring glutamic acid decarboxylase (GAD65) and tyrosine phosphatase like (IA-2) autoantibodies. Patients and

Methods:

120 diabetic children and 118 age and gender matched control children, were recruited for this study. Circulating levels of IL-1ß, IL-2 and IL-4 were measured by ELISA. GAD65 and IA-2 were measured by RIA.

Results:

Circulating levels of IL-1ß were elevated in type 1 diabetic children as compared to the control group (9.3±7.3 and 4.9±3.8 pg/ml respectively, p=0,01). Serum concentration of IL-2 was also higher in diabetic patients (19.8±13.1 and 11.3±9.1 pg/ml respectively, p=0,01). No differences in serum IL-4 were observed between diabetics and control. Diabetic children with one or two positive autoantibodies (IA-2 and/or GAD65) had significantly higher levels of IL-1ß and IL-2 and lower levels of IL-4 than diabetic children without positive autoantibodies. High concentrations of IL-1ß were associated with an early onset of the disease.

Conclusions:

High levels of IL-1ß and IL-2 were found in diabetic children with recent diagnosis of the disease. Diabetics with positive antibodies against GAD65 and IA-2 had higher levels of IL-1ß and IL-2 and lower levels of IL-4 than their counterparts without positive antibodies.
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Interleucina-1 / Diabetes Mellitus Tipo 1 Limite: Criança / Feminino / Humanos / Masculino País/Região como assunto: América do Sul / Chile Idioma: Espanhol Revista: Rev. méd. Chile Assunto da revista: Medicina Ano de publicação: 2004 Tipo de documento: Artigo País de afiliação: Chile Instituição/País de afiliação: Universidad de Chile/CL

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Interleucina-1 / Diabetes Mellitus Tipo 1 Limite: Criança / Feminino / Humanos / Masculino País/Região como assunto: América do Sul / Chile Idioma: Espanhol Revista: Rev. méd. Chile Assunto da revista: Medicina Ano de publicação: 2004 Tipo de documento: Artigo País de afiliação: Chile Instituição/País de afiliação: Universidad de Chile/CL
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