Effect of trypanosoma lewisi infection on the toxoplasma gondii multiplication in white rat peritoneal macrophages
Parasitol. latinoam
; 59(1/2): 3-7, Ene. 2004. ilus
Artigo
em Inglês
| LILACS
| ID: lil-383502
Biblioteca responsável:
CL1.1
RESUMO
Peritoneal macrophages (PM) from normal Wistar rats were treated in vitro with peritoneal supernatant or sera, obtained from rats infected with 106 Trypanosoma lewisi trypomastigotes before the infection with Toxoplasma gondii tachyzoites. In this experimental model, Toxoplasma multiplication in PM was increased, as compared to macrophages treated with supernatant or sera from control rats not infected with T. lewisi. This effect was observed only if the active supernatant or sera came from rats infected with the T. lewisi 3 to 6 d before Toxoplasma inoculation. Furthermore, immunosuppressive activity was only detectable after at least 24 h incubation with the supernatant or sera. These results are in accordance with our in vivo previous studies which demonstrated a clear immunosuppressive effect of T. lewisi during T.gondii infection of the remarkably resistant Wistar rats.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Doenças Negligenciadas
/
Zoonoses
Base de dados:
LILACS
Assunto principal:
Toxoplasma
/
Trypanosoma lewisi
/
Técnicas In Vitro
/
Terapia de Imunossupressão
/
Macrófagos Peritoneais
Limite:
Animais
Idioma:
Inglês
Revista:
Parasitol. latinoam
Assunto da revista:
Parasitologia
Ano de publicação:
2004
Tipo de documento:
Artigo
País de afiliação:
Costa Rica
Instituição/País de afiliação:
Universidad de Costa Rica/CR