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Frecuencia de genes y haplotipos del sistema HLA en la poblacion Panameña / Gene frequency and haplotypes of the HLA system in the Panamanian population
Vernaza-Kwiers, A. A; de Gómez, I. J; Díaz-Isaacs, M; Cuero, C. J; Pérez Guardia, E; Moreno Saavedra, M.
Afiliação
  • Vernaza-Kwiers, A. A; Caja de Seguro Social. CHMAAM. Servicios de Inmunología Especializada e Histocompatibilidad.
  • de Gómez, I. J; Caja de Seguro Social. CHMAAM. Servicios de Inmunología Especializada e Histocompatibilidad.
  • Díaz-Isaacs, M; Caja de Seguro Social. CHMAAM. Servicios de Inmunología Especializada e Histocompatibilidad.
  • Cuero, C. J; Caja de Seguro Social. CHMAAM. Servicios de Inmunología Especializada e Histocompatibilidad.
  • Pérez Guardia, E; Caja de Seguro Social. CHMAAM. Servicios de Inmunología Especializada e Histocompatibilidad.
  • Moreno Saavedra, M; Caja de Seguro Social. CHMAAM. Servicios de Inmunología Especializada e Histocompatibilidad.
Rev. méd. Panamá ; 20(3): 116-123, Sept. 1995.
Article em Es | LILACS | ID: lil-409931
Biblioteca responsável: BR1.1
ABSTRACT
The authors determined the frequency of genes and haplotypes of the HLA system in 965 panamanian men and women not related to each other, between 6 and 65 years of age. The HLA-A locus genes with the highest frequency (f) were A2, with f 0.1763; A24, f 0.1584; A30, f 0.1340; A23, f 0.1069; A3, f 0.0774. The other 20 genes each had less than 0.07. The genes with the highest frequency for locus HLA-B were B35, f 0.1946; B44, f 0.0904; B7, f 0.0774; B60 and B61, f 0.0582. For locus HLA-C, the most frequent genes were Cw3 with f 0.1549 and Cw4, f 0.1444. For locus HLA-DR, the most frequent genes were DR2 with f 0.1283; DR3, f 0.0620; DR7, f 0.0409. The most frequent haplotypes in the panamanian population were A2-B35 with f 0.0382; A3-B35, f 0.0191; A24-35, f 0.0287; A24-B61, f 0.0239; A29-B44, f 0.0287; A30-B42, f 0.0239; A23-B44, f 0.0191; A1-B8, f 0.0143. The authors conclude that the panamanian population exhibits a high degree of polymorphism for loci HLA-A, B and C, while for locu HLA-DR the frequency is the median when compared with that in caucasian, negro and oriental groups; and that, according to locus, predominant genes originating from these groups and found, corroborating the multiracial origen of the panamanian population
Assuntos
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Coleções: 01-internacional Base de dados: LILACS Assunto principal: Haplótipos / Frequência do Gene / Antígenos HLA Limite: Adolescent / Adult / Child / Female / Humans / Male País/Região como assunto: America central / Panama Idioma: Es Revista: Rev. méd. Panamá Assunto da revista: MEDICINA Ano de publicação: 1995 Tipo de documento: Article País de afiliação: Panamá País de publicação: Panamá
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Coleções: 01-internacional Base de dados: LILACS Assunto principal: Haplótipos / Frequência do Gene / Antígenos HLA Limite: Adolescent / Adult / Child / Female / Humans / Male País/Região como assunto: America central / Panama Idioma: Es Revista: Rev. méd. Panamá Assunto da revista: MEDICINA Ano de publicação: 1995 Tipo de documento: Article País de afiliação: Panamá País de publicação: Panamá