La biodiversidad humana y sus efectos sobre la variabilidad farmacologica: enzimas CYP2D6 y NAT2 en poblaciones amerindias de Panama, Colombia y Costa Rica / Human biodiversity and its effects on the pharmacological variability: CYP2D6 and NAT2 enzymes in Amerind populations of Panama, Colombia and Costa Rica
Rev. méd. Panamá
; 20(3): 98-107, Sept. 1995.
Artigo
em Espanhol
| LILACS
| ID: lil-409933
Biblioteca responsável:
BR1.1
ABSTRACT
Human biodiversity originates partially from human microevolution, which have produced different populations. This biodiversity is responsible for most of the variability in drug response. We present the methodology employed in population pharmacology studies and general information about the CYP2D6 and NAT2 systems. We report results obtained in Embera and Ngawbe Amerindians, who are characterized by a low phenotypic and genotypic CYP2D6 diversity. In regard to NAT2, Amerindians are distinguished by a high allelic frequency of S3 and low ones of S1 and S2, situation which is reversed in Caucasians
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Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Farmacogenética
/
Acetiltransferases
/
Variação Genética
/
Índios Centro-Americanos
/
Índios Sul-Americanos
/
Oxigenases de Função Mista
Limite:
Humanos
País/Região como assunto:
América Central
/
América do Sul
/
Colômbia
/
Costa Rica
/
Panamá
Idioma:
Espanhol
Revista:
Rev. méd. Panamá
Assunto da revista:
Medicina
Ano de publicação:
1995
Tipo de documento:
Artigo
País de afiliação:
Panamá