In vitro anti-proliferation/cytotoxic activity of sixty natural products on the human SH-SY5Y neuroblastoma cells with specific reference to dibenzyl trisulphide
West Indian med. j
; 53(4): 208-219, Sept. 2004.
Article
em En
| LILACS
| ID: lil-410433
Biblioteca responsável:
BR1.1
RESUMO
Sixty natural products belonging to the following structural classes artemisinins, coumarins, flavonoids, tannins, tetrahydroberberine alkaloids, tetracyclic triterpenes, tetranortriterpenoids and polysulphides were screened against the human SH-SY5Y neuroblastoma cell line revealing differences in their effects on cell morphology and in anti-proliferation/cytotoxic activity. Based on the data obtained, dibenzyl trisulphide is the most effective anti-proliferative/cytotoxic compound. In addition, we hereby propose the human SH-SY5Y cell line as a sensitive and uncomplicated in vitro test system for detecting compounds with potential anti-proliferation/cytotoxic activity
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Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Sulfetos
/
Compostos de Benzil
/
Extratos Vegetais
/
Neuroblastoma
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
West Indian med. j
Assunto da revista:
MEDICINA
Ano de publicação:
2004
Tipo de documento:
Article
País de publicação:
Jamaica