Diphtheria-neutralizing antibody levels in healthy adults from Rio de Janeiro, Brazil
Mem. Inst. Oswaldo Cruz
; 101(4): 459-462, June 2006. tab
Article
em En
| LILACS
| ID: lil-435310
Biblioteca responsável:
BR1.1
ABSTRACT
In Brazil, until 2004, the immunization policy against diphtheria involved childhood vaccination with no official routine booster dose administered after 15 years of age. This study assessed functional antibody levels against diphtheria among blood donors. A total of 140 blood samples were collected, and diphtheria antitoxin levels were evaluated by Vero cell neutralization test. The mean age of the population was 34 years old (range 18-61 years); 37.8 percent females and 62.2 percent males. Overall, 30.7 percent (95 percent, CI 23.4-38.7) individuals presented neutralizing antitoxin antibody titers < 0.01 IU/ml; 42.1 percent (95 percent, CI 34.1-50.4) showed values between 0.01-0.09 IU/ml and, 27.1 percent (95 percent, CI 20.2-34.9) had ³ 0.1 IU/ml. In the subgroup of individuals with history of diphtheria immunization during childhood (85 percent), a number of 28.5 percent showed unprotective levels of circulating neutralizing antibody (< 0.01 IU/ml). Despite the continuous progress of immunization programs directed to Brazilian population, currently healthy adults remain susceptible to diphtheria.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Toxoide Diftérico
/
Corynebacterium diphtheriae
/
Difteria
/
Anticorpos Antibacterianos
Limite:
Animals
/
Female
/
Humans
/
Male
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Ano de publicação:
2006
Tipo de documento:
Article
/
Project document
País de afiliação:
Brasil