Expresión inmunohistoquímica del complejo E-caderina-catenina en cáncer gástrico: Relación con variables clínico-morfológicas y sobrevida de pacientes / Immunohistochemical expression of the E-cadherin-catenin complex in gastric cancer
Rev. méd. Chile
; 134(8): 1002-1009, ago. 2006. ilus, tab
Article
em Es, En
| LILACS
| ID: lil-438371
Biblioteca responsável:
BR1.1
ABSTRACT
Background:
The E-cadherin/catenin complex plays an essential role in the control of epithelial differentiation. Abnormal expression in tumors correlates with histological grade, advanced stage and poor prognosis.Aim:
To evaluate the expression pattern of E-cadherin/catenin complex in gastric carcinoma and analyze their association with tumor clinicopathological features and patient survival. Material andMethods:
Inmunohistochemical staining of E-cadherin, alpha and ß-catenin was performed from paraffin specimens of 65 gastric carcinomas.Results:
Abnormal expression of E-cadherin, alpha and ß-catenin was demonstrated in 82 percent, 85 percent and 88 percent of gastric carcinomas, respectively. There was a significant correlation between abnormal expression and Lauren pathological classification and depth of infiltration, but not with tumor stage, positive lymph node metastases and survival.Conclusion:
Abnormal expression of E-cadherin, alpha and ß-catenin occurs frequently in gastric carcinoma and correlates with histological grade.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Neoplasias Gástricas
/
Caderinas
/
Beta Catenina
/
Alfa Catenina
/
Proteínas de Neoplasias
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
/
Male
País/Região como assunto:
America do sul
/
Chile
Idioma:
En
/
Es
Revista:
Rev. méd. Chile
Assunto da revista:
MEDICINA
Ano de publicação:
2006
Tipo de documento:
Article
/
Project document
País de afiliação:
Chile