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Biodistribution of 99m technetium- labeled creatinine in healthy rats
Yilmaz, O; Yurt Lambrecht, F; Soylu, A; Durkan, K; Kavukcu, S.
Afiliação
  • Yilmaz, O; Dokuz Eylul University. Medical Faculty. Department of Animal Research Center. Narlidere. TR
  • Yurt Lambrecht, F; Ege University. Institute of Nuclear Sciences. Department of Nuclear Applications. Narlidere. TR
  • Soylu, A; Dokuz Eylul University. Medical Faculty. Department of Pediatrics. Narlidere. TR
  • Durkan, K; Ege University. Institute of Nuclear Sciences. Department of Nuclear Applications. Narlidere. TR
  • Kavukcu, S; Dokuz Eylul University. Medical Faculty. Department of Pediatrics. Narlidere. TR
Braz. j. med. biol. res ; 40(6): 807-812, June 2007. graf
Artigo em Inglês | LILACS | ID: lil-452678
Biblioteca responsável: BR1.1
ABSTRACT
The distribution of creatinine, one of the toxic guanidine compounds, in various tissues has not been studied in detail by using radiolabeled creatinine. Our objective was to investigate the biodistribution of creatinine labeled with 99m technetium (99mTc) by the stannous (II) chloride method in healthy male Wistar rats. Quality controls were carried out by radio thin layer chromatography, high-performance liquid chromatography, and paper electrophoresis. The labeling yield was 85 ± 2 percent under optimum conditions (pH 7 and 100 æg stannous chloride). Rats (N = 12) were injected intravenously with 99mTc-creatinine and their blood and visceral organs were evaluated for 99mTc-creatinine uptake as percent of the injected dose per gram wet weight of each tissue ( percentID/g). The lowest amount of uptake was detected in the brain and testis. When the rate of uptake was evaluated, only the kidney showed increasing rates of uptake of 99mTc-creatinine throughout the study. Kidneys showed the highest amount of uptake throughout the study (P < 0.001 compared to all other organs), followed by liver, spleen and lung tissue.
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Tecnécio / Compostos Radiofarmacêuticos / Creatinina Limite: Animais Idioma: Inglês Revista: Braz. j. med. biol. res Assunto da revista: Biologia / Medicina Ano de publicação: 2007 Tipo de documento: Artigo País de afiliação: Turquia Instituição/País de afiliação: Dokuz Eylul University/TR / Ege University/TR

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Tecnécio / Compostos Radiofarmacêuticos / Creatinina Limite: Animais Idioma: Inglês Revista: Braz. j. med. biol. res Assunto da revista: Biologia / Medicina Ano de publicação: 2007 Tipo de documento: Artigo País de afiliação: Turquia Instituição/País de afiliação: Dokuz Eylul University/TR / Ege University/TR
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