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Associated risk factors and pulsed field gel electrophoresis of nasal isolates of Staphylococcus aureus from medical students in a tertiary hospital in Lagos, Nigeria
Adesida, Solayide A; Abioye, Olusegun A; Bamiro, Babajide S; Brai, Bartholomew I. C; Smith, Stella I; Amisu, Kehinde O; Ehichioya, Deborah U; Ogunsola, Folasade T; Coker, Akitoye O.
Afiliação
  • Adesida, Solayide A; Nigerian Institute of Medical Research. Molecular Biology and Biotechnology Division. Lagos. NG
  • Abioye, Olusegun A; University of Lagos. Faculty of Pharmacy. Dept. of Pharmaceutics and Pharmaceutical Technology. Yaba. NG
  • Bamiro, Babajide S; University of Lagos. College of Medicine. Department of Medical Microbiology and Parasitology. Yaba. NG
  • Brai, Bartholomew I. C; Nigerian Institute of Medical Research. Molecular Biology and Biotechnology Division. Lagos. NG
  • Smith, Stella I; Nigerian Institute of Medical Research. Molecular Biology and Biotechnology Division. Lagos. NG
  • Amisu, Kehinde O; University of Lagos. College of Medicine. Department of Medical Microbiology and Parasitology. Yaba. NG
  • Ehichioya, Deborah U; University of Lagos. College of Medicine. Department of Medical Microbiology and Parasitology. Yaba. NG
  • Ogunsola, Folasade T; University of Lagos. College of Medicine. Department of Medical Microbiology and Parasitology. Yaba. NG
  • Coker, Akitoye O; University of Lagos. College of Medicine. Department of Medical Microbiology and Parasitology. Yaba. NG
Braz. j. infect. dis ; 11(1): 63-69, Feb. 2007. tab, graf
Article em En | LILACS | ID: lil-454684
Biblioteca responsável: BR1.1
ABSTRACT
Staphylococcus aureus infections are growing problems worldwide with important implications in hospitals. The organism is normally present in the nasal vestibule of about 35 percent of apparently healthy individuals and its carriage varies between different ethnic and age groups. Staphylococcal nasal carriage among health workers is particularly important to establish new clones and track origin of infections during outbreak situations. To determine the carriage rate and compare the pulsed field gel patterns of the strains, nasal swabs were collected from 185 medical students in a teaching hospital in Lagos, Nigeria. Isolates of S. aureus were tested for heamolysin production, methicillin sensitivity and Pulsed Field Gel Electrophoresis (PFGE) was performed. The results showed S.aureus nasal carrier rate of 14 percent with significant rate among males compared to females. All the isolates produced heamolysin. Antibiotic susceptibility pattern revealed that majority of the isolates was susceptible. Five strains (19 percent) harboured resistant determinants to penicillin and tetracycline. None of the strains was resistant to methicillin. 44 percent of the isolates typed by PFGE had type B, the most predominant pulsotype. PFGE A clone exhibited a single resistance phenotype suggesting a strong clonal relationship that could punctual an outbreak in the hospital. The results speculate that nasal carriage among medical personnel could be a function of various risk factors. Personal hygiene and behaviour may however be the means to reducing colonization and spread of S.aureus in our hospitals.
Assuntos
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Infecções Estafilocócicas / Staphylococcus aureus / Portador Sadio / Resistência a Meticilina / Antibacterianos / Cavidade Nasal Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male País/Região como assunto: Africa Idioma: En Revista: Braz. j. infect. dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Nigéria País de publicação: Brasil
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Infecções Estafilocócicas / Staphylococcus aureus / Portador Sadio / Resistência a Meticilina / Antibacterianos / Cavidade Nasal Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male País/Região como assunto: Africa Idioma: En Revista: Braz. j. infect. dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Nigéria País de publicação: Brasil