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Antioxidant activity of extract from Polygonum cuspidatum
Hsu, Chin-Yuan; Chan, Yu-Pei; Chang, Jeli.
Afiliação
  • Hsu, Chin-Yuan; Chang Gung University. Department of Life Science. Tao-Yuan. CN
  • Chan, Yu-Pei; Chang Gung University. Department of Life Science. Tao-Yuan. CN
  • Chang, Jeli; Chang Gung University. Department of Life Science. Tao-Yuan. CN
Biol. Res ; 40(1): 13-21, 2007. ilus, tab
Artigo em Inglês | LILACS | ID: lil-456604
Biblioteca responsável: BR1.1
ABSTRACT
Numerous diseases are induced by free radicals via lipid peroxidation, protein peroxidation and DNA damage. It has been known that a variety of plant extracts have antioxidant activities to scavenge free radicals. Whether Polygonum cuspidatum Sieb. et Zuce has antioxidant activity is unknown. In this study, dried roots of Polygonum cuspidatum were extracted by ethanol and the extract was lyophilized. Free radical scavenging assays, superoxide radical scavenging assays, lipid peroxidation assays and hydroxyl radical-induced DNA strand scission assays were employed to study antioxidant activities. The results indicate that the IC50 value oí Polygonum cuspidatum extract is 110 µg/ml in free radical scavenging assays, 3.2 µg/ml in superoxide radical scavenging assays, and 8 µg/ml in lipid peroxidation assays, respectively. Furthermore, Polygonum cuspidatum extract has DNA protective effect in hydroxyl radical-induced DNA strand scission assays. The total phenolics and flavonoid content of extract is 641.1 ± 42.6 mg/g and 62.3 ± 6.0 mg/g. The results indicate that Polygonum cuspidatum extract clearly has antioxidant effects.
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Dano ao DNA / Peroxidação de Lipídeos / Fallopia japonica / Radicais Livres / Antioxidantes Idioma: Inglês Revista: Biol. Res Assunto da revista: Biologia Ano de publicação: 2007 Tipo de documento: Artigo / Documento de projeto País de afiliação: China Instituição/País de afiliação: Chang Gung University/CN

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Dano ao DNA / Peroxidação de Lipídeos / Fallopia japonica / Radicais Livres / Antioxidantes Idioma: Inglês Revista: Biol. Res Assunto da revista: Biologia Ano de publicação: 2007 Tipo de documento: Artigo / Documento de projeto País de afiliação: China Instituição/País de afiliação: Chang Gung University/CN
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