The hope for an HIV vaccine based on induction of CD8+ T lymphocytes: a review
Mem. Inst. Oswaldo Cruz
; 103(2): 119-129, Mar. 2008. ilus, graf
Article
em En
| LILACS
| ID: lil-480638
Biblioteca responsável:
BR1.1
ABSTRACT
The only long-term and cost-effective solution to the human immunodeficiency virus (HIV) epidemic in the developing world is a vaccine that prevents individuals from becoming infected or, once infected, from passing the virus on to others. There is currently little hope for an AIDS vaccine. Conventional attempts to induce protective antibody and CD8+ lymphocyte responses against HIV and simian immunodeficiency virus (SIV) have failed. The enormous diversity of the virus has only recently been appreciated by vaccinologists, and our assays to determine CD8+ lymphocyte antiviral efficacy are inadequate. The central hypothesis of a CTL-based vaccine is that particularly effective CD8+ lymphocytes directed against at least five epitopes that are derived from regions under functional and structural constraints will control replication of pathogenic SIV. This would be somewhat analogous to control of virus replication by triple drug therapy or neutralizing antibodies.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Vírus da Imunodeficiência Símia
/
Vacinas contra a AIDS
/
Epitopos de Linfócito T
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Ano de publicação:
2008
Tipo de documento:
Article
/
Project document
País de afiliação:
Estados Unidos
País de publicação:
Brasil