Analysis of the clinicopathological characteristics of patients with upper urinary tract transitional cell carcinoma
Clinics
; 63(2): 223-228, 2008. graf, tab
Article
em En
| LILACS
| ID: lil-481052
Biblioteca responsável:
BR1.1
ABSTRACT
OBJECTIVE:
To describe the clinicopathological characteristics of patients with upper urinary tract transitional cell carcinomas who are treated surgically and to analyze the occurrence of bladder tumors as well as the development of metastases outside the urinary tract. MATERIALS ANDMETHODS:
The study comprised a retrospective analysis of 25 patients treated between February 1994 and August 2006. The variables analyzed were patient age, gender, and clinical presentation; diagnostic methods; pathologic characteristics at the primary site of the tumor (pelvis or ureter); tumor stage and grade; and presence of carcinoma in situ, microvascular invasion and squamous differentiation. The Kaplan-Meier method and the Log-Rank test were used for statistical analysis of bladder recurrence-free survival.RESULTS:
Eighty-four percent of patients were male, and macroscopic hematuria was the most common clinical presentation. The majority of cases (56 percent) were infiltrative (T2-T3) and high-grade (76 percent) tumors. Synchronous or metachronous bladder tumors were found in 72 percent of cases. Five (20 percent) patients had a history of bladder tumor before the diagnosis of upper urinary tract transitional cell carcinomas. The mean follow-up period was 36 months (range 1.5 to 156). During the follow-up period, eleven (44 percent) patients developed bladder tumors. After five years, the probability of being free of bladder tumor recurrence was 40 percent. No pathological variable was predictive for bladder tumor recurrence. Four patients presented disease recurrence outside the urinary tract.CONCLUSIONS:
The presence of metachronous bladder tumors is more often observed after the diagnosis of upper urinary tract transitional cell carcinomas. All of these patients should undergo rigorous follow-up during the postoperative period. Only patients with infiltrative and high-grade tumors developed metastases outside the urinary tract.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Neoplasias Ureterais
/
Carcinoma de Células de Transição
/
Neoplasias Renais
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Clinics
Assunto da revista:
MEDICINA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Brasil