Your browser doesn't support javascript.
loading
Systemic Radionuclide Therapy of Painful Prostate Cancer Bone Metastases With Samarium-153-edtmp
Lima, Carmen Silvia Passos; Etchebehere, Elba Cristina Sá de Camargo; Dicke, Eduardo; Pereira Neto, Carlos Araújo Cunha; Lima, Mariana Cunha Lopes de; Santos, Allan de Oliveira; Ramos, Celso Darío; Silva, Cleide Maria; Camargo, Edwaldo Eduardo.
Afiliação
  • Lima, Carmen Silvia Passos; State University of Campinas. Faculty of Medical Sciences. Department of Internal Medicine - Clinical Oncology Service. Campinas. BR
  • Etchebehere, Elba Cristina Sá de Camargo; State University of Campinas. Faculty of Medical Sciences. Department of Radiology, Division of Nuclear Medicine. Campinas. BR
  • Dicke, Eduardo; State University of Campinas. Faculty of Medical Sciences. Department of Internal Medicine - Clinical Oncology Service. Campinas. BR
  • Pereira Neto, Carlos Araújo Cunha; State University of Campinas. Department of Radiology, Division of Nuclear Medicine. Campinas. BR
  • Lima, Mariana Cunha Lopes de; State University of Campinas. Department of Radiology, Division of Nuclear Medicine. Campinas. BR
  • Santos, Allan de Oliveira; State University of Campinas. Department of Radiology, Division of Nuclear Medicine. Campinas. BR
  • Ramos, Celso Darío; State University of Campinas. Department of Radiology, Division of Nuclear Medicine. Campinas. BR
  • Silva, Cleide Maria; State University of Campinas. Department of Radiology, Division of Nuclear Medicine. Campinas. BR
  • Camargo, Edwaldo Eduardo; State University of Campinas. Department of Radiology, Division of Nuclear Medicine. Campinas. BR
Appl. cancer res ; 27(1): 12-17, Jan.-Mar. 2007.
Artigo em Inglês | LILACS, Inca | ID: lil-481540
Biblioteca responsável: BR30.1
ABSTRACT
Most patients with prostate cancer (PC) will develop painful bone metastases, which alters their quality of life.

Objective:

This study aimed to evaluate the efficacy and toxic hematological profile of samarium for the treatment of PC metastases’ bone pain.

Methods:

Twenty-nine PC patients (median age 69 years, range 46-84; Gleason score equal to or higher than 7 in 66.7% and under 7 in 33.3% of patients presenting multiple painful bone metastases were treated with intravenous injection of 153Sm-EDTMP. Response to treatment was defined as either a reduction of at least 25% in patient’s pain score, using a 0 to 10 scale (score 0 no pain, score 10 maximum pain), or in daily analgesic dosage. Complete blood counts were performed before 153Sm–EDTMP administration and 4 and 8 weeks after treatment with the purpose of evaluating hematological side effects of the agent.

Results:

Twenty-five patients (86.2%) responded to treatment (median time 1.5 month, range 1.0 to 2.0 months). A reduction equal to or higher than 25% in post-treatment values compared to baseline values was seen in hemoglobin (Hb) of 3 (12.0%) patients, in leukocytes (Lo) of 16 (64.0%) patients, and in platelets (Pl) of 19 (76.0%) patients. Hb under 10g/dl, Lo under 2.0x103/ul, and Pl under than 50.0x103/ul were seen in 7 (28.0%), 3 (12.0%) and 2 (8.0%) out of 25 patients analyzed after 153Sm–EDTMP, respectively. No infectious or bleeding episodes were seen in any patient during the study.

Conclusion:

153Sm-EDTMP is effective for acute control of PC patients’ bone pain. However, additional studies with bone marrow assessment before and after 153Sm–EDTMP are necessary to clarify the origin of cytopenias found in our cases.
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS / Inca Assunto principal: Neoplasias da Próstata / Samário / Radionuclídeo Limite: Humanos / Masculino Idioma: Inglês Revista: Appl. cancer res Assunto da revista: Neoplasias Ano de publicação: 2007 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: State University of Campinas/BR

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS / Inca Assunto principal: Neoplasias da Próstata / Samário / Radionuclídeo Limite: Humanos / Masculino Idioma: Inglês Revista: Appl. cancer res Assunto da revista: Neoplasias Ano de publicação: 2007 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: State University of Campinas/BR
...