Indications of a new antibiotic in clinical practice: results of the tigecycline initial use registry
Braz. j. infect. dis
; 12(3): 198-201, June 2008. tab
Artigo
em Inglês
| LILACS
| ID: lil-493647
Biblioteca responsável:
BR1.1
ABSTRACT
Tigecycline is the first of a new class of antibiotics named glycylcyclines and it was approved for the treatment of complicated intra-abdominal infections and complicated skin and skin structure infections. Notwithstanding this, tigecycline's pharmacological and microbiological profile which includes multidrug-resistant pathogens encourages physicians' use of the drug in other infections. We analyzed, during the first months after its launch, the tigecycline prescriptions for 113 patients in 12 institutions. Twenty-five patients (22 percent) received tigecycline for approved indications, and 88 (78 percent) for "off label" indications (56 percent with scientific support and 22 percent with limited or without any scientific support). The most frequent "off label" use was ventilator associated pneumonia (VAP) (63 patients). The etiology of infections was established in 105 patients (93 percent). MDR-Acinetobacter spp. was the microorganism most frequently isolated (50 percent of the cases). Overall, attending physicians reported clinical success in 86 of the 113 patients (76 percent). Our study shows that the "off label" use of tigecycline is frequent, especially in VAP. due to MDR-Acinetobacter spp., where the therapeutic options are limited (eg colistin). Physicians must evaluate the benefits/risks of using this antibiotic for indications that lack rigorous scientific support.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Zoonoses
Base de dados:
LILACS
Assunto principal:
Infecções Bacterianas
/
Minociclina
/
Antibacterianos
Tipo de estudo:
Ensaio clínico controlado
/
Estudo observacional
/
Fatores de risco
Limite:
Adolescente
/
Adulto
/
Idoso
/
Idoso, 80 anos ou mais
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Braz. j. infect. dis
Assunto da revista:
Doenças Transmissíveis
Ano de publicação:
2008
Tipo de documento:
Artigo
País de afiliação:
Argentina
/
Chile
Instituição/País de afiliação:
CEMIC/AR
/
Center of Research in Infectious Diseases/AR
/
Clínica Ciudad/AR
/
Clínica San Camilo/AR
/
FLENI Instituto de Investigaciones Dr.Raúl Carrea/AR
/
Hospital Dr. Eduardo Castro Rendón/AR
/
Hospital Español/AR
/
Hospital Italiano/AR
/
Hospital Ramos Mejía/AR
/
Instituto Cardiovascular de Buenos Aires/AR