HIV - ELISA negativo com NAT positivo: uma realidade em Hemoterapia: [carta ao editor] / HIV - Negative ELISA and positive NAT: a reality in Blood Banking: [letter to editor]

ABSTRACT

Transfusion safety is a major concern all over the world with newtechnologies being developed to increase the protection of patients.Developed countries and some Brazilian private blood banks havealready implemented tests to detect HIV and HCV nucleic acid material(NAT). Despite the increase in transfusion safety promoted bythese tests, financers and administrators are resistant to pay for itswidespread implementation. We report here on the detection of awindow period for HIV identified by the NAT test: A donor candidateshowed up at the blood bank in August 2007 and after a clinicalinterview and hematological screening he was considered suitablefor donation and did not choose self-exclusion. All serologic testswere negative except NAT for HIV. Twelve days after donating, thedonor returned to draw another blood sample, which was positivefor NAT for HIV and combined ELISA Ag/Ab. On this occasion, hereported that he was being treated for pneumonia and had hadhomosexual relationships within the 4 weeks preceding blooddonation. One week after this second sample, a third one wascollected, which resulted in being positive for NAT, ELISA Ag/Aband ELISA HIV ½. This report illustrates the importance ofperforming the most sensitive serologic screening tests possible inblood donors, and reiterates the responsibility of physicians, hospitalsand financers. It is important to emphasize the obligation of usingevery available resource in order to increase transfusion safety asneglect is an ethical infraction with legal responsibilities. Rev. bras.hematol.hemoter.2008; 30(4):330-331.