Nuevos tratamientos para la infección por virus de hepatitis C y el proceso de fibrosis hepática: [revisión] / Novel treatments for hepatitis C viral infection and the hepatic fibrosis: [revision]
Rev. méd. Chile
; 137(2): 280-288, feb. 2009. ilus, tab
Artigo
em Espanhol
| LILACS
| ID: lil-516096
Biblioteca responsável:
BR1.1
ABSTRACT
Hepatitis C virus (HCV) infection represents a global health problem due to its evolution to hepatic cirrhosis and hepatocellular carcinoma. The viral pathogenesis and infectious processes are not yet fully understood. The development of natural viral resistance towards the host immune system represents a mayor challenge for the design of alternative therapeutic interventions and development of viral vaccines. The molecular mechanisms of hepatic fibrosis are well described. New alternatives for the treatment of patients with HCV infection and hepatic cirrhosis are under intensive research. New drugs such as viral protease inhibitors and assembly inhibitors, as well as immune modulators have been studied in clinical trials. Additional alternatives include antifibrotic drugs, which reverse the hepatic cellular damage caused by HCV infection. This review makes reference to viral infective mechanisms, molecular pathways of liver fibrosis and overviews conventional and new treatments for HCV infection and liver fibrosis.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
ODS3 - Meta 3.7 Acesso universal aos serviços de saude reprodutiva
/
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Infecções Sexualmente Transmissíveis: Prevenção e Cuidados
/
Meta 3.8 Atingir a cobertura universal de saúde
Base de dados:
LILACS
Assunto principal:
Hepatite C Crônica
/
Cirrose Hepática
Limite:
Humanos
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2009
Tipo de documento:
Artigo
País de afiliação:
México
Instituição/País de afiliação:
Universidad de Guadalajara/MX