Mixture of betel leaf, areca nut and tobacco chewing is a risk factor for cytogenetic damage in construction workers from south India
Braz. j. oral sci
; 8(3): 145-148, July-Sept. 2009. tab
Artigo
em Inglês
| LILACS, BBO - Odontologia
| ID: lil-563323
Biblioteca responsável:
BR28.1
ABSTRACT
Aim:
To determine the cytogenetic effect of betel leaf, areca nut and tobacco mixture usage among female construction workers in Tamilnadu, Southern India.Methods:
Totally 236 buccal cells and blood samples were collected from 80 betel quid users and 76 users with tobacco snuffing habit which were compared with 80 healthy subjects. Peripheral blood leukocyte cultures were analyzed for chromosomal aberrations (CA) and exfoliated cells from the buccal mucosa were examined for micronucleus (MN).Results:
Statistically significant (p<0.01) increase in CA and MN were observed in users with snuffing habit when compared to users without snuffing habit and controls as confirmed by chi-square test. Therefore, specific biomarkers on cytogenetic endpoints might help in planning precautionary measures to reduce oral cancer risks.Conclusions:
The present study can be concluded that a mixture of betel quid, areca nut and tobacco chewing/snuffing is unsafe for oral health. The genotoxic effect of smokeless tobacco should be considered in addition to other known hazards for assessing health risks.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
BBO - Odontologia
/
LILACS
Assunto principal:
Areca
/
Extratos Vegetais
/
Aberrações Cromossômicas
/
Tabaco sem Fumaça
/
Micronúcleos com Defeito Cromossômico
Tipo de estudo:
Estudo de etiologia
/
Fatores de risco
Limite:
Adulto
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Braz. j. oral sci
Assunto da revista:
Odontologia
Ano de publicação:
2009
Tipo de documento:
Artigo
País de afiliação:
Índia
Instituição/País de afiliação:
Karpagam University/IN