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Influence of anti-filarial chemotherapy strategies on the genetic structure of Wuchereria bancrofti populations
Ramasamy, Dhamodharan; Laxmanappa, Hoti Sugeerappa; Sharma, Rohit; Das, Manoj Kumar.
Afiliação
  • Ramasamy, Dhamodharan; Indian Council of Medical Research. Vector Control Research Centre. Puducherry. IN
  • Laxmanappa, Hoti Sugeerappa; Indian Council of Medical Research. Vector Control Research Centre. Puducherry. IN
  • Sharma, Rohit; Indian Council of Medical Research. Vector Control Research Centre. Puducherry. IN
  • Das, Manoj Kumar; Indian Council of Medical Research. National Institute of Malaria Research. Ranchi. IN
Mem. Inst. Oswaldo Cruz ; 106(2): 240-247, Mar. 2011. ilus, mapas, tab
Article em En | LILACS | ID: lil-583952
Biblioteca responsável: BR1.1
ABSTRACT
Lymphatic filarial (LF) parasites have been under anti-filarial drug pressure for more than half a century. Currently, annual mass drug administration (MDA) of diethylcarbamazine (DEC) or ivermectin in combination with albendazole (ALB) have been used globally to eliminate LF. Long-term chemotherapies exert significant pressure on the genetic structure of parasitic populations. We investigated the genetic variation among 210 Wuchereria bancrofti populations that were under three different chemotherapy strategies, namely MDA with DEC alone (group I, n = 74), MDA with DEC and ALB (group II, n = 60) and selective therapy (ST) with DEC (group III, n = 34) to understand the impact of these three drug regimens on the parasite genetic structure. Randomly amplified polymorphic DNA profiles were generated for the three groups of parasite populations; the gene diversity, gene flow and genetic distance values were determined and phylogenetic trees were constructed. Analysis of these parameters indicated that parasite populations under ST with a standard dose of DEC (group III) were genetically more diverse (0.2660) than parasite populations under MDA with DEC alone (group I, H = 0.2197) or with DEC + ALB (group II, H = 0.2317). These results indicate that the MDA may reduce the genetic diversity of W. bancrofti populations when compared to the genetic diversity of parasite populations under ST.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Variação Genética / Wuchereria bancrofti / Ivermectina / Albendazol / Dietilcarbamazina / Filaricidas Limite: Animals / Humans Idioma: En Revista: Mem. Inst. Oswaldo Cruz Assunto da revista: MEDICINA TROPICAL / PARASITOLOGIA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Índia País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Variação Genética / Wuchereria bancrofti / Ivermectina / Albendazol / Dietilcarbamazina / Filaricidas Limite: Animals / Humans Idioma: En Revista: Mem. Inst. Oswaldo Cruz Assunto da revista: MEDICINA TROPICAL / PARASITOLOGIA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Índia País de publicação: Brasil