Effects of diabetes on myocardial capillary density and serum angiogenesis biomarkers in male rats
Clinics
; 66(8): 1419-1424, 2011. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-598398
Biblioteca responsável:
BR1.1
ABSTRACT
INTRODUCTION:
Cardiovascular disease is one of the main causes of mortality and morbidity in diabetic patients. This study evaluated the effects of diabetes on myocardial capillary density and several serum angiogenic factors including nitric oxide, vascular endothelial growth factor, and soluble vascular endothelial growth factor receptors.METHODS:
Twelve male rats were divided into two groups control and diabetic (n = 6 each). Diabetes was induced with a single dose of streptozotocin (50 mg/kg). After 21 days, capillary density in the myocardial tissue was evaluated using immunohistochemical staining and is reported as capillaries per mm². Blood samples were collected before and after the induction of diabetes.RESULTS:
In the diabetic group, serum nitric oxide and soluble vascular endothelial growth factor receptor 2 concentrations were lower than the levels in the control group, while the level of soluble vascular endothelial growth factor receptor 1 was significantly higher. There was no significant change in the serum vascular endothelial growth factor concentration between the diabetic and control groups; however, the ratio of vascular endothelial growth factor to vascular endothelial growth factor receptor 1 was significantly lower in the diabetic animals. The myocardial capillary density was also lower in the diabetic group compared with the control group (1549 ± 161 vs. 2156 ± 202/mm², respectively).CONCLUSION:
Reduced serum nitric oxide and vascular endothelial growth factor receptor 2 levels, increased serum vascular endothelial growth factor receptor 1 levels and a lower vascular endothelial growth factor to vascular endothelial growth factor receptor 1 ratio may be responsible for the decreased myocardial capillary density in diabetic rats.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Diabetes Mellitus
/
Doenças do Sistema Endócrino
Base de dados:
LILACS
Assunto principal:
Capilares
/
Receptores de Fatores de Crescimento do Endotélio Vascular
/
Fatores de Crescimento do Endotélio Vascular
/
Diabetes Mellitus Experimental
/
Miocárdio
/
Neovascularização Patológica
/
Óxido Nítrico
Limite:
Animais
Idioma:
Inglês
Revista:
Clinics
Assunto da revista:
Medicina
Ano de publicação:
2011
Tipo de documento:
Artigo
País de afiliação:
Irã
Instituição/País de afiliação:
Isfahan University of Medical Sciences/IR